Date	Topic	Reading Assignments o to be completed before class on specified date	Written Assignments o to be completed before class on specified date. o be prepared to submit your assignment for review at the beginning of class upon request of the instructor.
Jan 19	Course Overview Introduction to Nanoscience	Syllabus handout	· Complete online SURVEYS posted at link sent in email to class · Bio 350 students: SCHEDULE MEETING with Ms. Mellissa Burk, Course GA, before February 2 to discuss internship application statements
Jan 26	The Origins and Basic Physics of Nanoscience GUEST SPEAKER: Dr. Boris Kiefer, Physics Department, NMSU	o NNI Big Things from a Tiny World o Feynman’s “Plenty of Room at the Bottom” o Ch 4, The Brownian Universe, Physics at the Nanoscale (Soft Machines)	Web-based INQUIRY EXERCISE in preparation for the lecture: o What is the predicted population increase over the next 25 years? o What is the predicted increase in energy demand related to the population increase? o Name and document (briefly) four societal challenges for science and technology in the 21st century. o Name and document (briefly) two applications of energy concepts in life science and engineering o Who was Richard Feynman and what is his contribution to nanoscience? o Provide 3 examples of a nanoscale objects
Feb 2	Nanoscience Internship Applications Nanobioscience basics	o NT pp. 11-35 (Ch 2,Size Matters; Ch 3, Fundamental science of Nanotechnology) o NT pp 83-106 (Ch 6, Smart Materials; Ch 7, Sensors) o NT pp 107-120 (Ch 8, Biomedical Applications; Ch 9, Optics) o SM pp 15-38, 146-153 (Ch 2, Looking at the Nanoworld; Ch 6, Motors)	CAREER DEVELOPMENT visit these websites for student internships and bring information about 3 INTERNSHIPS that interest you to class. GAME SHOW/Bio 350 o Inquisitors: Prepare questions using the text assigned to your team. Each team member should prepare 15 questions. Prepare a mixture of T/F, multiple choice, open ended questions o Competitors, Read same material. Be prepared for team competition! o Team Text Assignments Bio 350 Team 1 NT pp. 11-35 (Ch 2,Size Matters; Ch 3, Fundamental science of Nanotechnology) Bio 350 Team 2 NT pp 83-106 (Ch 6, Smart Materials; Ch 7, Sensors) Bio 350 Team 3 NT pp 107-120 (Ch 8, Biomedical Applications; Ch 9, Optics) Bio 550 Team 4 SM pp 15-38, 146-153 (Ch 2, Looking at the Nanoworld; Ch 6, Motors)
Feb 9	Fluorescence Nanocrystal Quantum Dots Nanoengineering	Websites and articles: Be sure to login from NMSU internet to read the articles o http://www.invitrogen.com/site/us/en/home/References/Molecular-Probes-The-Handbook/Introduction-to-Fluorescence-Techniques.html o http://micro.magnet.fsu.edu/primer/techniques/fluorescence/fluorointrohome.html o http://www.evidenttech.com/quantum-dots-explained.html o http://probes.invitrogen.com/media/publications/600.pdf o http://physicsworld.com/cws/article/print/17016 o Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics (Michalet et al) [online (NMSUBB)]	Bio 350 Submit draft personal and research statements suitable for internship applications (50 points) 1) Principles of Fluorescence. Access the following link and be prepared to explain the following figures: Fig 1, 2, 4, 1.96, 1.54, 10.56, 2.28 o http://www.invitrogen.com/site/us/en/home/References/Molecular-Probes-The-Handbook/Introduction-to-Fluorescence-Techniques.html Access the following link and complete the tutorials for Jablonski diagram, solvent effects and photobleaching http://micro.magnet.fsu.edu/primer/techniques/fluorescence/fluorointrohome.html 2) Quantum dots come to class ready to answer the following: What are QDs made of? How do QDs work? What are their optical properties? What are applications for QDs in biology? What are the concerns about QDS and biological systems (cells, organisms)
Feb 16	Bioenergetics & Photosynthesis Molecular Motors Academic Honesty (Burk)	Read o Soft NanoMachine Text o Ch 6 Machines and Mechanisms (pp 146-153) o Ch 8 Single Molecule Electronics (pp 186-195) o View the Photosynthesis Animation o http://www.cnr.vt.edu/dendro/forestbiology/photosynthesis.swf o Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics (Michalet et al) [online (NMSUBB)]	1) Be prepared to discuss the QD literature from Feb 9 and to answer to these questions: o Provide examples of linear and rotary motors in nature o How are conventional solar cells and photosynthesis similar and different? o Who is Michael Graetzel and what did he invent? 2) Bring pictures of the hypothetical three-dimensional structures of two biomolecular motors of your choice as determined by Xray and other diffraction methods. This website may be useful: http://www.ncbi.nlm.nih.gov/Structure/index.shtml 3) Bring a picture of your favorite Nanobot to class
Feb 23	Nanomaterials and BioToxicity GUEST SPEAKER: Dr. Kevin Houston, Chemistry & Biochemistry, NMSU	Read the article by Dr. Houston posted on Blackboard	Bio 350 Submit revised personal and research statements suitable for internship applications (50 points) Bring 3 questions to ask Dr. Huston based on your reading of his article. You will hand submit these questions to the GA at the beginning of class.
Mar 2	Measuring the Invisible Ethical and Societal Dimensions of Nanoscience Research Reading the Primary Literature	Read o How to Read a Scientific Paper o Nanotechnology and the Developing World (Salamanca-Buentello et al) [online (NMSUBB)] o Single molecule nanobioscience (Akihiko Ishijima and Toshio Yanagida) [online (NMSUBB)] o Quantum dots are powerful multipurpose vital labeling agents in Zebrafish embryos (Rieger et al) [online (NMSUBB)] o View movies online under supplemental materials	Submit Journal Part 1 in class (300 points) Print this picture and bring to class: o http://nobelprize.org/educational_games/physics/microscopes/powerline/index.html For each paper: o Be prepared to discuss the papers and explain the figures. o Bring a list to class of up to 10 key concepts presented in the paper o If the papers raise ethical issues or concerns please summarize them briefly for class discussion
Mar 9	Reading the Primary Literature Design Challenge	Last day to drop with W Read o Nanotechnology and the Developing World: Will Nanotechnology Overcome Poverty or Widen Disparities? (Invernizzi and Foladori) [online (NMSUBB)] o Applications of Nanobiotechnology in Clinical Diagnostics (Jain) [online (NMSUBB)] o Nanoparticles: pharmacological and toxicological significance (Medina et al) [online (NMSUBB)]	Be prepared to discuss the papers and explain the figures. For each paper: o Be prepared to discuss the papers and explain the figures. o Bring a list to class of up to 10 key concepts presented in the paper o If the papers raise ethical issues or concerns please summarize them briefly for class discussion
Mar 16	Lab Demos	View the tutorials before the class: Scanning Electron Microscopy (SEM) http://micro.magnet.fsu.edu/primer/java/electronmicroscopy/magnify1/index.html Transmission Electron Microscopy (TEM) http://nobelprize.org/educational_games/physics/microscopes/tem/index.html http://nobelprize.org/educational_games/physics/microscopes/tem/preparation.html http://nobelprize.org/educational_games/physics/microscopes/tem/gallery/index.html Atomic Force Microscopy (AFM) http://www.jpk.com/what-is-atomic-force-microscopy.432.html GRADS READ: Crystallisation, structure and function of plant light-harvesting Complex II (Barros, Kühlbrandt) [online (NMSUBB)]	Bio 550 Submit draft 2 page research proposal (50 points) Bring a sample to scan of woody plant or mineral origin.
Mar 23	Spring Break	Vacation!	n/a
Apr 20	Student Dissemination Presentations	Not applicable	Bio 550 Submit revised 2 page research proposal (50 points) Submit Journal Part 2 in class (300 points) Present dissemination project (150 points)
May 6 Finals Week	Date/time in official schedule for courses that meet Tuesday at 3:30	Final Exam (150 points) Thursday May 6 3:30-5:30 pm	Final Exam (150 points) Thursday May 6 3:30-5:30 pm

---