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New Mexico State University

Jiannong Xu
xu

Jiannong Xu


Title: Assistant Professor
Research area: Gut microbial ecology of malaria vector mosquitoes
Office location: FH 469
Laboratory Location:  FH 449
Email Address: jxu@nmsu.edu
Office Phone: 646-7713
Lab Phone: 646-5936


Education:

  • PhD: 1993, Second Military Medical University, Shanghai, China
  • Postdoctoral fellow: 1998-2003, New York University, Dept of Molecular and Medical Parasitology
  • Research Associate: 2003-2008, University of Minnesota, Dept of Microbiology.

  Research Interests  
Metagenomics of mosquito gut ecosystem
Mosquito guts accommodate a dynamic symbiotic microbiota that is essential for various mosquito life traits, such as fecundity and immunity against malaria.  We are using metagenomic and metatranscriptomic sequencing to characterize the genetic composition and functionality of the mosquito gut microbiome. The comprehensive understanding of the symbiotic relationship between mosquito and its gut microbial community will facilitate to develop novel ways to interfere with mosquito physiology and reduce vector competence.  

 

Teaching
Biol 550/450 Genomics
Biol 550/450 Bioinformatics
Biol 219 Public Health Microbiology
Biol 550 Ecological Immunology
Biol 478 Molecular Biology of Microorganisms

Selected publications

  1. Kukutla P, Steritz M, Xu J. (2012). "Depletion of Ribosomal RNA for Mosquito Gut Metagenomic RNA-seq. JoVE  (In Press)
  2. Alvarez C, Kukutla C, Jiang J, Yu W, & Xu J. (2012) Draft genome sequences of Pseudomonas sp. Ag1 isolated from the midgut of malaria mosquito Anopheles gambiae. J Bacteriol 194 (19):5449
  3. Jiang J, Alvarez C, Kukutla P, Yu W, & Xu J. (2012) Draft genome sequences of the isolate of Enterobacter sp.Ag1 from the midgut of the malaria mosquito Anopheles gambiae. J Bacteriol 194(19):5481
  4. Wang Y, Gilbreath TM, Kukutla P, Yan G, Xu J (2011) Dynamic gut microbiome across life history of the malaria mosquito Anopheles gambiae in Kenya. PLoS One
  5. Ma Y, Yang M, Fan Y, Wu J, Ma Y, Xu J. (2011) Population Structure of the Malaria Vector Anopheles sinensis (Diptera: Culicidae) in China: Two Gene Pools Inferred by Microsatellites. PLoS One 6(7):e22219
  6. Mitri C, Jacques JC, Thiery I, Riehle MM, Xu J, Bischoff E, Morlais I, Nsango SE, Vernick KD, Bourgouin C (2009) Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species. PLoS Pathog 5(9): e1000576 PMID: 19750215
  7. Riehle MM, Xu J, Lazzaro BP, Rottschaefer SM, Coulibaly B, Sacko M, Niare O, Morlais I, Traore SF, Vernick KD (2008) Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. PLoS ONE. 2008; 3(11): e3672. PMID: 18989366
  8. Riehle MM, Markianos K, Niare O, Xu J, Li J, Toure AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traore SF, Vernick KD (2006) Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science 312:577  PMID: 16645095
  9. Ma, J., Li, S. & Xu, J (2006) Molecular identification and phylogeny of the Maculatus Group of Anopheles mosquitoes (Diptera: Culicidae) based on nuclear and mitochondrial DNA sequences. Acta Tropica 99:272  PMID: 17052677
  10. Li J, Riehle MM, Zhang Y, Xu J, Oduol F, Gomez SM, Eiglmeier K, Ueberheide BM, Shabanowitz J, Hunt DF, Ribeiro JM, Vernick KD (2006) Anopheles gambiae genome reannotation through synthesis of ab initio and comparative gene prediction algorithms. Genome Biol. 7(3):R24  PMID: 16569258
  11. Ma, J. & Xu, J (2005) The Hyrcanus Group of Anopheles (Anopheles) in China (Diptera: Culicidae): species discrimination and phylogeny inferred by rDNA ITS2 sequences. J. Med. Entomol; 42:610 PMID: 16119550
  12. Vernick KD, Oduol F, Lazzaro BP, Glazebrook J, Xu J, Riehle M, Li J.(2005) Molecular genetics of mosquito resistance to malaria parasites. Curr Top Microbiol Immunol. 295:383 PMID: 16265899
  13. Christophides GK, Evgeny C, Barillas-Mury C, Birney E, Blandin S, Blass C, Bray PT, Collins FH, Danielli A, Dimopoulus G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina E, Loukeris TG, Lycett, G, Meister S,Michel K, Noita LF, Mueller H-M, Osta MA, Paskewitz, SM, Reichhart J, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, Kafatos FC. (2002) Immunity-related genes and gene families in Anopheles gambiae: A comparative genomic analysis. Science; 298:159 PMID: 12364793
  14. Oduol, F., Xu, J., Niare, O., Natarajan, R & Vernick, K. D. (2000) Genes identified by an expression screen in the vector mosquito, Anopheles gambiae, display differential molecular immune response to malaria parasites and bacteria. Proc Natl Acad Sci U S A. 97:11397 PMID: 11005829
  15. Xu, X, Xu, J & Qu, F (1998) A diagnostic polymerase chain reaction assay for species A and D of the Anopheles dirus (Diptera: Culicidae) species complex based on ribosomal DNA second internal transcribed space sequence. J Am Mosq Control Assoc; 14:385 PMID: 10084131
  16. Xu, J & Qu, F (1997) Ribosomal DNA difference between species A and D of the Anopheles dirus complex of mosquitoes from China. Med Vet Entomol; 11:134 PMID: 9226641