Biology 520/Molecular Biology 520

MOLECULAR CELL BIOLOGY

Instructor: Dr. Elba Serrano

Schedule

Lecture: MW 1:30-2:45 p.m. in Biology Foster Hall 110

Instructor: Dr. Elba Serrano
Associate Professor of Biology
Ph. D., Stanford University, Biological Sciences/Biophysics

Office: Foster Hall 337D
Office hours: Mon and Wed, 11:30 am-12:30 pm. Sign up on sheet outside FH 337D
Telephone: X65217
email: eserrano@nmsu.edu

TA: Laura Haas, X61618, Foster Hall Rm 115, lhaas@nmsu.edu

Textbook: Molecular Biology of the Cell Fourth Edition Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter © 2002

Prerequisites: Introductory Biochemistry or undergraduate level Cell Biology.

Goals: This course is intended to provide the advanced student with a thorough foundation in the fundamental principles that underlie cell structure and function. The lectures will focus on the biology of eucaryotic cells. Emphasis will be placed throughout the course on developing written and verbal skills appropriate for the graduate-level student. Many assignments will focus on developing problem solving and creative thinking skills. Students will be required to prepare oral presentations, and conduct substantial library research and independent investigation. At the discretion of the instructor, undergraduates who have completed Biology 377, Cell Biology. or Biology 490, Neurobiology, may also enroll in the course.

Course structure: The course is divided in two sections.

Part I: Students will review and expand their understanding of the foundations of Molecular Cell Biology. This portion of the course follows the book closely. The journal assignment is prepared in parallel with this first half of the course, and will integrate key concepts around more specific themes. Students will access the primary literature for this assignment.
Part II: The second part of the course develops knowledge of selected Special Topics. Oral presentations are emphasized in this section of the course. Students will prepare two oral presentations, one on an assigned journal article and one on material compiled for the journal assignment. Guest faculty and staff will present lectures on research and methods pertinent to Molecular Cell Biology. Demonstrations of confocal, scanning electron, transmission electron, light, and fluorescence microscopy will be included as part of the course.
Grading and exams: A total of 1000 pts may be earned during the semester.

Exams: (520 points) There will be three written in class exams. Exams will include short and long essay questions, definitions, true/false, and multiple choice questions.

Exam dates: Midterm Exam 1 Mon, Oct 6 (150 pts)
Midterm Exam 2 Mon, Nov 10 (150 pts)
Cumulative Final Wed, Dec 10 (220 pts) 1-3 pm
Problem set: (80 pts) One problem set will be assigned, and will review the material in Part 1 of the course. The problem set is due Wed October 15.

In class participation:(40 pts) Based on your contribution to class discussion.

Attendance: (40 pts) Students are expected to attend all classes.

Journal assignments: (220 points) Students will be required to maintain a journal during the semester. The objective of this assignment is for students to integrate multiple concepts at the cellular level. The journal will be prepared by conducting extensive library and Internet research on topics that we cover in class, as they relate to a cell type, a protein, and an organsm that students will select at the beginning of the semester. The journal will allow students to acquire depth in specific areas of cell biology related to their research specialty. The written portion of the journal will be evaluated twice during the semester for a total of 200 points.
Journal due dates:
Part 1: Mon, Oct 13 (110 pts)
Part 2: Mon. Nov 17 (110 pts)
Journal presentations: (50 pts). Students will be required to prepare a 30 minute oral presentation around a theme related to their journal research.

Journal article presentations: (50 pts). Students will be required to read and make oral presentations on assigned journal articles from the primary literature. The presentations will be made by students in groups of 2 or 3. Students will be evaluated by group members as well as by the instructor.

Grade Scale:

A 900-1000 pts
B 800-899 pts
C 700-799 pts
D 600-699 pts
F < 600 pts

Note: The grade scale may be curved at the end of the semester at the discretion of the instructor.

Deadline to drop: October 15

Save: Save xeroxes of all graded assignments and exams from this course at least until you have received your final grade.

Readings
Wed  Aug
20 
Intro/Background Evaluation
Mon  Aug
25 
Ch 8 &9 Chromosomes & RNA synthesis& Gene expression Ch 8 &9
Wed  Aug
27 
Ch 10 Membrane Structure Ch 10
Mon  Sept
2
>>>Labor Day<<<
Wed  Sept
Ch 11 Membrane Transport Ch 11
Mon  Sept
Ch 12 Cell Compartmentalization&ProteinTrafficking Ch 12
Wed  Sept
10 
Ch12/13 Protein Trafficking & Vesicular Traffic Ch12/13
Mon  Sept
15 
Ch 14 Bioenergetics/Cell Signalling Ch 14
Wed  Sept
17 
Ch 15 Structural Cell Biology: Confocal microscope demo Ch 15
Mon  Sept
22 
Ch 15/16 Cell Signalling/Cytoskeleton Ch 15/16
Wed  Sept
24 
Ch 16 Cytoskeleton Ch 16
Mon  Sept
29 
Ch 19 Extracellular Matrix
Wed  Oct
Ch 17 Cell Cycle Ch 19
Mon  Oct
>>>Exam 1<<< Ch 17
Wed  Oct
Ch 22 Cell Differentiation Ch 16
Mon  Oct
13 
Discussion/Review
>>>Journal Part 1 due<<<
Part II: Special Topics
Wed  Oct
15 
Ch 11 Special topics: Neurobiology
>>>Problem Set due<<<
Mon  Oct
20 
Ch 21 Special topics: Development Ch 22
Wed  Oct
22 
Assigned Journal Articles
Mon  Oct
27 
Ch 4 Structural Cell Biology: Microscopy techniques Ch 4
Wed  Oct
29 
Structural Cell Biology: Electron Microscope Lab
Mon  Nov
Assigned Journal Articles
Wed  Nov
Assigned Journal Articles
Mon  Nov
10 
>>>Exam 2<<<
Wed  Nov
12 
Assigned Journal Articles
Mon  Nov
17 
Guest Faculty: Dr. Phillips " Plant Cell Culture"
>>>Journal Part II due<<<
Wed  Nov
19 
Guest Faculty: Dr. Warburton "Muscle and Heart"
Mon  Nov
24 
Student Journal Reports
Wed  Nov
26 
Thanksgiving
Mon  Dec
Student Journal Reports
Wed  Dec
Student Journal Reports
Wed Dec
10 
>>>FINAL EXAM 1-3 pm<<<

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urnal Reports Wed Dec
10 
>>>FINAL EXAM 1-3 pm<<<

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